Early-Stage Alpha — Waiting List Open

Clinical-grade pedigree analysis,
finally in your browser

Evagene unifies pedigree drawing, clinical data modelling, and Bayesian risk analysis in a single platform. Standard ISCN/HGNC notation. Integrated BayesMendel engine (BRCAPRO, MMRpro, PancPRO). A 184-disease catalog with ICD-10 and OMIM codes. Zero installs.

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Standard pedigree notation (ISCN/HGNC) Per-individual consent-to-share flags No installation required
BayesMendel R engine (peer-reviewed) ICD-10 & OMIM coded
evagene.net/pedigree/brca-family
Three-generation BRCA pedigree with standard genetic notation and integrated BRCAPRO risk results
184 Diseases
6 Risk Models
The Problem

Existing pedigree tools cost clinicians time, not save it

Paper charts get lost in handover. General-purpose diagramming tools don't understand affection fill or proband arrows. Legacy genetics software forces you to re-key family data into a separate BayesMendel calculator — and none of it runs in a browser.

The result: consultation time wasted on tools rather than patients. Incompatible exports between research teams. Families locked out of their own history.

Evagene

Draw. Annotate. Analyse. Export. One tab.

Evagene combines gesture-based pedigree drawing, deep clinical data modelling, Bayesian risk analysis, and universal data exchange — in a single browser application with no installation.

Draw a circle for a female. A square for a male. Connect them. Add diseases with ICD-10 codes. Run BRCAPRO. Export to PDF. That is the entire workflow.

Explore capabilities

A complete pedigree platform, not another drawing tool

From gesture-based canvas drawing to Bayesian cancer risk models and GEDCOM interoperability — clinical-grade power in an interface anyone can learn in minutes.

Gesture Drawing

Freehand-draw circles, squares, and diamonds on the HTML5 canvas. Draw lines to form relationships. Natural as pen and paper, with keyboard accelerators.

MFUPshortcuts

ISCN/HGNC Notation

Internationally recognised pedigree symbols: affection fill, carrier dots, half-fill, mortality overlays, consanguinity double-lines, proband arrows, and fertility indicators.

Rich Properties Editor

Floating draggable panel: identity (8 biological sex options), death status (12 options), lifestyle, contact fields, consent-to-share flags, relationship events — all synced in real time.

184-Disease Catalog

Oncology, cardiology, neurology, metabolic — each entry carries ICD-10, OMIM, inheritance pattern, penetrance tables, and carrier frequencies by ethnicity.

Bayesian Risk Models

BRCAPRO, MMRpro, PancPRO via the peer-reviewed BayesMendel engine. Plus autosomal dominant/recessive and X-linked Mendelian models with age-dependent penetrance.

Interactive Karyogram

Ideogram of all chromosomes with genetic markers at genomic positions, colour-coded by test result (positive / VUS / negative), with centromere bands.

Broad Data Exchange

Import JSON, GEDCOM 5.5.1, XEG, 23andMe, and images (OCR). Export to JSON, GEDCOM, PNG (up to 4x), SVG, and PDF (A4/A3/Letter/Legal).

Consanguinity & Kinship

Wright's path coefficient calculates consanguinity coefficients automatically. Values display on relationship lines and feed directly into risk models.

Advanced Search

Query builder: filter by sex, disease status, age, tests, treatments — across parents, siblings, ancestors, descendants. AND/OR modes. Results highlighted on canvas.

Batch Investigation

Screen a proband across multiple diseases simultaneously. Generate dual-audience reports: one written for the patient, one for the clinical geneticist.

Allergies & Traits

59 allergies (severity, IgE, cross-reactivity). 51 traits (heritability, marker associations). Enables genotype-phenotype correlation in a unified model.

Auto-Layout & UX

Algorithm-based positioning respecting family structure. Undo/redo, copy/paste, lasso select, snap-to-grid, pinch zoom, light/dark theme, configurable fonts.

Ready to draw your first pedigree?

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Purpose-built for every user who works with pedigrees

From specialist geneticists to patients documenting family history — Evagene adapts to your workflow and expertise level.

Replace paper charts and workarounds with a purpose-built system

Every symbol, fill pattern, and overlay follows standard clinical pedigree conventions — eliminating the ambiguity of hand-drawn charts and the limitations of diagramming tools.

  • Run BRCAPRO, MMRpro, PancPRO, and Mendelian risk models directly from the pedigree — no re-entering data
  • 184 diseases pre-configured with ICD-10, OMIM, inheritance patterns, penetrance data, and ethnicity-specific carrier frequencies
  • Batch investigation: screen a proband across multiple conditions with structured dual-audience reports
  • Linkage analysis: LOD scores, flanking markers, haplotype tables, Haldane/Kosambi map functions
Pedigree canvas + risk panel
CanvasRisk PanelRisk by age table
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Major Differentiator

Integrated BayesMendel risk analysis — no second tool needed

The BayesMendel R engine runs as a sidecar process. Select a proband, choose a model, click Run Analysis. Carrier probabilities and age-specific risk tables appear in the same panel — no copy-paste, no data re-entry.

BRCAPRO

Breast & Ovarian Cancer

BRCA1/BRCA2 carrier probability. Cumulative breast and ovarian cancer risk at ages 40, 50, 60, 70, 80.

Populations: General, Ashkenazi Jewish, Italian
Carrier ≥10% → clinically actionable
Carrier ≥25% → strongly suggestive
MMRpro

Lynch Syndrome

MLH1/MSH2/MSH6 carrier probability. Colorectal and endometrial cancer risk by age. ~3% of all CRC.

Supports Amsterdam II criteria context
Carrier ≥5% → consider IHC/MSI testing
PancPRO

Pancreatic Cancer

Pancreatic cancer susceptibility. FPC families face 5–30× general-population risk.

Genes: PALB2 and others
Lifetime risk >5% → consider EUS/MRI screening

See it in action: simulated BRCAPRO output

Select a family scenario below to see how carrier probabilities and risk change with family history.

BRCA1 carrier probability2.1%
BRCA2 carrier probability1.4%
Breast cancer risk by age 7014.2%

Below clinical action threshold. General-population screening applies.

Mendelian Inheritance Models

Built-in models for autosomal dominant, autosomal recessive, and X-linked recessive. Advanced parameters:

Age-dependent penetranceGermline mosaicismDe novo mutation ratesAnticipation (trinucleotide)Parent-of-origin biasLocus heterogeneityLinkage disequilibriumLOD scores
6
Risk models
184
Diseases catalogued
2
Report audiences
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Speaks every format your workflow demands

Import from clinical systems, genealogy platforms, and consumer genomics. Export publication-ready output in any format.

FormatImportExportNotes
JSON✓✓Full snapshot; replace or add mode
GEDCOM 5.5.1✓✓Ancestry, FamilySearch, Gramps compatible
XEG✓—Legacy Evagene v1 XML migration
23andMe✓—Genotype, ancestry, DNA relatives, phenotype
Image✓—OCR + shape detection from chart photos
PNG—✓1x–4x scale, optional transparency
SVG—✓Vector for publication-quality output
PDF—✓A4/A3/Letter/Legal, portrait/landscape/auto
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200+ built-in guides, from beginner to expert

Every disease name, genetic marker, and risk result in Evagene links directly to its guide. The help system doubles as a comprehensive genetics education resource.

184
Disease-specific guides
8
Role-specific workflows
3
Genetics knowledge levels
6
Risk model explainers

Covers the central dogma (DNA → RNA → protein), chromosome structure, Mendelian inheritance patterns, and how mutations lead to disease. Written for readers with no prior genetics background. Includes diagrams of DNA replication, meiosis, and autosomal vs. X-linked inheritance.

BRCAPRO uses Bayesian updating with the BayesMendel R package to estimate BRCA1/BRCA2 carrier probability from family pedigree data. Supports General, Ashkenazi Jewish, and Italian population frequencies. Carrier probability ≥10% is considered clinically actionable; ≥25% is strongly suggestive of hereditary breast and ovarian cancer syndrome.

ICD-10: C50. OMIM: 114480. Inheritance: multifactorial with high-penetrance genes (BRCA1, BRCA2, TP53, PALB2). Lifetime risk ~12% general population; up to 72% for BRCA1 carriers. Evagene tracks laterality, ER/PR/HER2 status, grade, stage, and age at diagnosis per individual.

M/F/U to add individuals, P for partner, D for disease palette, N for notes, G for genetics panel. Ctrl+Z/Y for undo/redo, Ctrl+C/V for copy/paste, Ctrl+A to select all, F2 to edit name, Delete to remove. Space+drag to pan, scroll to zoom, Ctrl+G for snap-to-grid.

Alpha Access

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Be among the first to use Evagene. Alpha members receive early access, direct input on the roadmap, and priority support from the development team.

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Alpha spots are limited

Join clinicians, researchers, and families already on the waiting list. Early members shape the roadmap and receive priority support.

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