Cross-source consensus on what matters today in genetics and genomics — drawn from 16 trusted public sources including NHGRI, the CDC, NHS England, Genomics England, the PHG Foundation, the Wellcome Sanger Institute, and peer-reviewed open-access journals.
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A late-stage trial of mRNA-4157/V940 combined with pembrolizumab met its primary endpoint in advanced melanoma, according to data reported by Moderna and Merck.
Regeneron's antibody treatment for fibrodysplasia ossificans progressiva — an ultra-rare genetic disorder in which bone forms progressively in soft tissue — has received FDA approval under the brand name Pasatru.
A preprint reports two novel deep-intronic variants in PCDH15 that disrupt splicing in Usher syndrome patients who had previously received no genetic diagnosis, and demonstrates antisense oligonucleotide rescue in a minigene model.
NHS England begins distributing home HPV self-sampling kits to women aged 30–65 who have not responded to cervical screening invitations, aiming to increase uptake.
The US Food and Drug Administration has again paused a Regenxbio clinical trial for Hunter syndrome following new safety signals, underscoring ongoing challenges in adeno-associated virus gene therapy development.
Specialists in gene editing have questioned the study design and technical choices made by Huidagene Therapeutics in a Duchenne muscular dystrophy trial in which a patient died.
A machine-learning analysis of around 500,000 DNA sequences has characterised the initiator element — a core promoter signal — at unprecedented scale, offering a route to predicting the impact of non-coding mutations.
A preprint demonstrates that the minor spliceosome snRNA U4atac controls cilium biogenesis in the developing zebrafish brain by regulating splicing of minor introns in two ciliary genes, connecting RNU4ATAC-associated syndromes to ciliopathy.
A random forest classifier integrating protein structural context, evolutionary conservation, and gene constraint offers calibrated PP3/BP4 thresholds for variant classification.
A PHG Foundation analysis sets out why the pathway for UK participation in the EU's cross-border health data framework is still legally and politically unclear.
About Genetic Current
Genetic Current is the news section of Evagene, an academic, research, and educational pedigree-modelling platform. Stories are AI-drafted summaries of items from trusted public sources, written for researchers, clinicians, educators, students, genealogists, and patients with an interest in genetics. Summaries are for educational and research purposes only and are not medical advice.
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