Cross-source consensus on what matters today in genetics and genomics — drawn from 16 trusted public sources including NHGRI, the CDC, NHS England, Genomics England, the PHG Foundation, the Wellcome Sanger Institute, and peer-reviewed open-access journals.
Last updated: · browse archive
Novartis has reported seven previously unknown instances of tumour development in paediatric patients who received its spinal muscular atrophy gene therapy, Zolgensma.
STAT News reports that a small number of tumour cases now provide strong evidence that AAV vectors used in gene therapy can, in rare instances, cause cancer — a risk long debated in the field.
STAT News reports that a small number of documented tumour cases now provide substantive evidence that AAV vectors used in gene therapy can cause cancer in some recipients.
A PLOS Genetics study of 175 Rwandan women with breast cancer identifies a recurrent BRCA1 frameshift variant in unrelated carriers, highlighting gaps in germline data from African populations.
PepGen says its antisense candidate is correcting more of the pathological RNA splicing that underlies myotonic dystrophy type 1, according to early-phase trial results reported by STAT News.
Researchers at UC San Francisco report that a brain-activated version of CAR-T cell therapy wiped out diffuse midline glioma in two mouse models, offering a potential new approach for a childhood brain cancer with almost no survivors.
A preprint using three large genetic biobanks identifies 121 genomic loci associated with anellovirus levels in blood, with NF-κB immune signalling emerging as the dominant host-control pathway.
Servier has reported a surprise negative result for sevasemten — the asset it acquired for $1.55 billion — in a phase trial for Becker muscular dystrophy, a condition that currently has no approved disease-modifying treatment.
A PLOS Genetics study using population-scale genomic data finds that germline TERT variants are more common than clinically ascertained cohorts suggest, with phenotype associations that differ from those observed in specialist referral populations.
A bioRxiv preprint uses long-read sequencing and ancestry-aware methods to characterise genetic and epigenetic variation in a large, admixed Hispanic/Latino cohort, identifying candidate associations absent from existing reference datasets.
About Genetic Current
Genetic Current is the news section of Evagene, an academic, research, and educational pedigree-modelling platform. Stories are AI-drafted summaries of items from trusted public sources, written for researchers, clinicians, educators, students, genealogists, and patients with an interest in genetics. Summaries are for educational and research purposes only and are not medical advice.
Join the Evagene Alpha Waiting List